• 硫链丝菌肽

  • 产品编号:60846
    CAS号:1393-48-2
  • 别名:硫链丝菌素 分子式:C72H85N19O18S5 分子量:1664.89
  • 订货编号
  • 规格
  • 包装
  • 单价
  • 优惠价
  • COA
  • 数量
  • A60846-1g
  • ≥98% (HPLC)
  • 1g
  • 1994.00
  • 化学性质

    属性

    密度
    1.6400
    溶解性
    Soluble in DMSO (10 mg/ml), chloroform (10 mg/ml), dioxane, pyridine, glacial acetic acid, and DMF. Insoluble in water
    存贮条件
    储存温度:-20℃

    描述

    产品介绍
    Thiostrepton is a cyclic peptide antibiotic, densely packed with thiazoles and other structurally intriguing moieties. Thiostrepton exhibits antibiotic activity through blockade of ribosome turnover after an elongation step in protein synthesis by inhibiting both the dissociation of elongation factor G (EF-G) from the ribosome and the release of inorganic phosphate from EF-G following GTP hydrolysis. Thiostrepton is also described to show efficacy against cancer cell growth through downregulation of the forkhead box M1 (FOXM1) transcription factor, commonly overexpressed in many malignancies. Thiostrepton is an inhibitor of FOXM1
    别名
    硫链丝菌素;Bryamycin; Thiactin; Alaninamide
    生化机理
    肽抗生素,阻止延长因子G(EF-G)和GTP结合到50S核糖体亚单元上
    应用
    A protein synthesis-inhibiting antibiotic

    危险性质

    标识符号
    GHS07 GHS07
    信号词
    Warning
    安全声明(欧洲)
    危害声明
    个人防护设备
    Eyeshields,Gloves,type N95 (US),type P1 (EN143) respirator filter
    RTECS
    XN6300100
    WGK德国
    3

    相关资料

  • 硫链丝菌素技术资料

    分子式:1664.89 CAS号:1393-48-2

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